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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2AK4
All Species:
23.03
Human Site:
Y1047
Identified Species:
50.67
UniProt:
Q9P2K8
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9P2K8
NP_001013725.2
1649
186838
Y1047
S
P
A
I
D
Y
T
Y
D
S
D
I
L
K
G
Chimpanzee
Pan troglodytes
XP_001140245
1649
186793
Y1047
S
P
A
I
D
Y
T
Y
D
S
D
I
L
K
G
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535431
1633
184740
Y1050
S
P
A
I
D
Y
T
Y
D
S
N
M
P
K
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZ05
1648
186468
Y1046
S
P
A
I
D
Y
T
Y
D
S
D
I
L
K
G
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518247
1608
180821
Y1006
S
P
A
I
D
Y
T
Y
D
S
D
V
L
K
G
Chicken
Gallus gallus
XP_421203
1656
188583
Y1053
S
P
A
I
D
Y
T
Y
D
S
D
T
L
K
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667149
1483
168725
P935
L
K
S
D
L
L
P
P
P
Q
M
E
E
S
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120977
1130
130476
S582
S
H
Q
F
C
S
F
S
P
S
S
V
K
L
M
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_785160
1605
181469
P1054
L
E
S
K
L
L
P
P
P
Q
M
E
D
A
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LX30
1241
140303
L693
N
L
K
L
K
G
E
L
P
L
K
W
V
N
E
Baker's Yeast
Sacchar. cerevisiae
P15442
1659
190175
N1027
T
N
D
I
L
F
D
N
S
V
P
T
S
T
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
N.A.
89.7
N.A.
90.5
N.A.
N.A.
74.7
72.3
N.A.
52.6
N.A.
N.A.
27.9
N.A.
40.4
Protein Similarity:
100
99.9
N.A.
94.3
N.A.
94.9
N.A.
N.A.
84.4
84.5
N.A.
67.4
N.A.
N.A.
44
N.A.
59.4
P-Site Identity:
100
100
N.A.
80
N.A.
100
N.A.
N.A.
93.3
93.3
N.A.
0
N.A.
N.A.
13.3
N.A.
0
P-Site Similarity:
100
100
N.A.
93.3
N.A.
100
N.A.
N.A.
100
93.3
N.A.
6.6
N.A.
N.A.
20
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.5
26.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.7
46.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
55
0
0
0
0
0
0
0
0
0
0
10
0
% A
% Cys:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
10
10
55
0
10
0
55
0
46
0
10
0
0
% D
% Glu:
0
10
0
0
0
0
10
0
0
0
0
19
10
0
19
% E
% Phe:
0
0
0
10
0
10
10
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
55
% G
% His:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
64
0
0
0
0
0
0
0
28
0
0
0
% I
% Lys:
0
10
10
10
10
0
0
0
0
0
10
0
10
55
0
% K
% Leu:
19
10
0
10
28
19
0
10
0
10
0
0
46
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
19
10
0
0
10
% M
% Asn:
10
10
0
0
0
0
0
10
0
0
10
0
0
10
0
% N
% Pro:
0
55
0
0
0
0
19
19
37
0
10
0
10
0
10
% P
% Gln:
0
0
10
0
0
0
0
0
0
19
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% R
% Ser:
64
0
19
0
0
10
0
10
10
64
10
0
10
10
0
% S
% Thr:
10
0
0
0
0
0
55
0
0
0
0
19
0
10
0
% T
% Val:
0
0
0
0
0
0
0
0
0
10
0
19
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% W
% Tyr:
0
0
0
0
0
55
0
55
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _